publication date: Oct. 20, 2016

Non-Small Cell Lung Cancer Phase III Tecentriq Study Shows Better Survival vs. Chemo Regardless of PD-L1 Status

Genentech said its pivotal phase III OAK study of Tecentriq (atezolizumab) showed a median survival of 13.8 months, 4.2 months longer than those treated with docetaxel chemotherapy (median overall survival [OS]: 13.8 vs. 9.6 months; HR = 0.73, 95% CI: 0.62 – 0.87).

The results were presented at the European Society of Medical Oncology 2016 Annual Meeting in Copenhagen.

The OAK study evaluated people with non-small cell lung cancer whose disease had progressed on or after treatment with one or more platinum-based chemotherapy (second-line and third-line).

The study enrolled people regardless of their programmed death-ligand 1 (PD-L1) status and included both squamous and non-squamous disease types. Adverse events were consistent with those observed in previous Tecentriq studies.

“Tecentriq is the first and only anti-PD-L1 cancer immunotherapy to help people with metastatic NSCLC live significantly longer than chemotherapy regardless of their PD-L1 expression level or their disease histology,” Sandra Horning, chief medical officer and head of global product development, said in a statement. “Even people whose disease had low or no observed PD-L1 expression still showed a significant benefit from the medicine.”

Genentech is a member of the Roche Group.

FDA granted Breakthrough Therapy Designation for Tecentriq for the treatment of PD-L1-positive NSCLC … Continue reading CCL Oct 2016 – Phase III Tecentriq Study Shows Better Survival vs. Chemo Regardless of PD-L1 Status

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