Issue 24 - Jun 15, 2018
  • Guest Editorial

    The Trump administration “American Patients First” plan to reduce drug prices—Are American cancer patients first?

    In May 2018, President Trump announced his plan to lower drug prices. “We will have tougher negotiation, more competition, and much lower prices at the pharmacy counter. And it will start to take effect very soon,” he promised. The plan is outlined in a 40-page document by the U.S. Department of Health and Human Services titled “American Patients First—The Trump Administration Blueprint to Lower Drug Prices and Reduce Out-of-Pocket Cost.”

  • Change in culture needed to prevent sexual harassment at academic institutions, NASEM says

    To prevent and effectively respond to sexual harassment of women, institutions of higher education need to promote a system-wide change to the culture and climate on campus, says a new report from the National Academies of Sciences, Engineering, and Medicine.

  • In Brief

    • NCI’s Rosenberg receives Jacobson Innovation Award of the American College of Surgeons
    • Penn State Health and Highmark Health to create health care network
    • NCI renews City of Hope’s support grant with outstanding rating
    • AAP recognizes COH’s Forman for physician-led science and scientific leadership
    • COH’s Rosen inducted into the College of Fellows of the American Institute for Medical and Biological Engineering
    • Prostate cancer expert Dorff joins COH
    • COH’s Djulbegovic directs Medicine and Comparative Effectiveness Research Program
  • Funding Opportunities

    NCI Community Oncology Research Program issues three RFAs: Community Sites, Minority/Underserved Community Sites, and Research Bases

    This Funding Opportunity Announcement solicits applications from institutions/organizations to participate in the National Cancer Institute’s NCI Community Oncology Research Program (NCORP).

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  • Letter to the Editor

    MammaPrint has remained consistent and credible since introduction more than a decade ago

    To the Editor:

    One of the biggest questions that early-stage breast cancer patients face is whether they will benefit from chemotherapy treatment. Two large scale randomized clinical trials that implement genomic testing have positively addressed this question.

  • Clinical Roundup

    • Study shows low-fat diet significantly reduced risk of death after breast cancer
    • Some African-American men with advanced prostate cancer do better than whites
    • African-American men show stronger response to hormone therapy for prostate cancer
    • Loxo announces positive interim data from dose escalation trial in RET-altered cancers
    • Tecentriq, Avastin plus chemo improved OS in non-squamous NSCLC
    • Alecensa reduced risk of disease progression or death in Alk-positive metastatic NSCLC
    • Checkpoint inhibitor shrinks advanced squamous cell skin cancer
    • Kisqali combination therapy improves PFS in HR+/HER2- breast cancer
    • PARP inhibitor improves overall response rates in small cell lung cancer patients
    • Study links blood vitamin D levels to colorectal cancer risk


  • Drugs and Targets

    • FDA approves Avastin in combination with chemotherapy for ovarian cancer
    • FDA approves Keytruda for relapsed or refractory PMBCL
    • FDA approves Keytruda for previously treated patients with recurrent or metastatic cervical cancer whose tumors express PD-L1
    • TESARO, Genentech to study Zejula with anti-PD-L1 agent, MEK inhibitor in ovarian cancer
    • FDA approves Venclexta with rituximab as a fixed duration treatment for CLL or SLL after one prior therapy
    • FDA approves first Neulasta biosimilar
    • FDA, EMA accept application for talazoparib in metastatic breast cancer with inherited BRCA mutation
  • The Cancer Letter wins investigative, design awards

    The Cancer Letter won four 2018 Dateline Awards from the Washington, D.C. Chapter of the Society of Professional Journalists.

Issue 23 - Jun 8, 2018
  • Big takeaway from ASCO: 70 percent of women with early breast cancer don’t benefit from adjuvant chemotherapy

    An NCI-sponsored trial showed that up to 70 percent of women with hormone receptor-positive, HER2-negative, axillary lymph node-negative breast cancer would not benefit from chemotherapy.

  • Conversation with The Cancer Letter

    Abrams: Only about 20-30 percent of the group might benefit from chemotherapy

    The practice-changing TAILORx trial was brought to you by publicly funded cancer clinical trials system, pointing to its continuing relevance, said Jeff Abrams, NCI acting director for clinical research and associate director of the Cancer Therapy Evaluation Program.

  • Sharpless: NCI adds $10 million for NCTN and NCORP trials

    NCI is providing an additional $10 million to support trials run with the National Clinical Trials Network and the NCI Community Oncology Research Program, Norman “Ned” Sharpless said in his first appearance as NCI director at the annual meeting of the American Society of Clinical Oncology in Chicago. “NCI’s major efforts with regards to large clinical trials are largely supported through our clinical trials networks like the National Clinical Trials Network,” Sharpless said in his June 2 talk at ASCO. “One of the major challenges for these networks over the past few years, however, has been a rapid increase in the per-patient costs for patients on trials.

  • In Brief

    • J&J Innovation and Boston University form lung cancer research alliance
    • Kochevar to retire from Colorado Cancer Center
  • Funding Opportunities

    Addario, Van Auken foundations announce 2018 Young Innovators Team Award

    The Bonnie J. Addario Lung Cancer Foundation, in collaboration with the Van Auken Private Foundation, announced the 2018 Young Innovators Team Award to fund and support teams of young investigators conducting innovative research with a potential of delivering meaningful and measurable results in the field of lung cancer.

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  • Trials and Tribulations

    Searching for Breast Cancer’s “Extreme Survivors” 

    I remember the day I met Margaret “Peg” Geisler, who has now been living with breast cancer for 40 years, and with metastatic disease for 36 of those years.

  • Clinical Roundup

    • New treatment combination improves outcomes for some patients with colorectal cancer
    • Exact Sciences, Mayo Clinic identify blood-based DNA biomarkers to diagnose hepatocellular carcinoma
    • Opdivo demonstrates superior RFS vs. Yervoy for patients with resected stage III or IV melanoma
    • Opdivo plus Yervoy provide QOL improvements in RCC
Issue 22 - Jun 1, 2018