Issue 28 - Jul 13, 2018
  • Immunologists seek ways to make TIL in solid tumors as effective as CAR T in blood cancers

    For more than four decades, Steven Rosenberg’s work on tumor infiltrating lymphocytes has met with equal measures of skepticism and cheer—but now, as more patients across multiple cancer types respond to cell transfer immunotherapy, researchers are eager to join the movement Rosenberg indisputably leads.

  • Conversation with The Cancer Letter

    NCI’s Rosenberg: Tumor infiltrating lymphocytes offer a strategy for treating recalcitrant solid cancers

    After achieving complete regression in several patients with different solid tumor types, Steven Rosenberg is eyeing the biggest prize imaginable—advancing the therapies he has championed for over four decades into the clinic as treatments for commonly occurring cancers.

  • House committee proposes $1.25 billion raise for NIH

    The fiscal year 2019 spending bill marked up by the House Committee on Appropriations gives NIH a $1.25 billion raise.

    “The National Institutes of Health, our nation’s premier biomedical agency, is funded at $1.25 billion above last year’s appropriation,” said Rep. Tom Cole (R-OK), Labor-HHS subcommittee chair.

  • In Brief

    • Gerstle named chief of Pediatric Surgery Service at MSK
    • Pestell joins CytoDyn as chief medical officer
    • Beck named COO at Leukemia & Lymphoma Society
    • UCLA’s Ribas named “Great Immigrant” by Carnegie Corp.
    • Abbott joins the Fox Chase Department of Diagnostic Imaging
  • TCCL Logo

  • Clinical Roundup

    • ACA credited with earlier diagnosis of gynecologic cancers in young women
    • Phase III trial of Ninlaro meets PFS primary endpoint in multiple myeloma
    • New blood test measures four protein biomarkers, can help identify lung cancer
  • Drugs & Targets

    • FDA grants accelerated approval to Yervoy for MSI-H or dMMR metastatic colorectal cancer
    • FDA approves Xtandi sNDA for CRPC
    • FDA grants Priority Review to Merck’s sBLA for Keytruda for advanced hepatocellular carcinoma
    • Genentech submits sNDA for Venclexta for an AML indication
Issue 27 - Jul 6, 2018
Issue 26 - Jun 29, 2018
  • Senate committee proposes $2 billion raise for NIH, signaling fourth good year in a row

    When the Senate Committee on Appropriations marked up the fiscal 2019 spending bill, NIH came out ahead—$2 billion ahead.

  • NCI Director’s Report

    What NCI did with the money: Sharpless boosts funding for RPGs, centers, SPOREs, NCTN, and NCORP

    In addition to a $147 million increase to the Research Grant Project pool, NCI has added $60 million to targeted research opportunities and a $20 million increase for centers and SPOREs, and $10 million for the National Clinical Trials Network and the NCI Community Oncology Research Program.

  • Turkish oncologist Murat Tuncer jailed

    A. Murat Tuncer, a pediatric oncologist and former rector of Hacettepe University, has spent the past two months in a very uncomfortable place—the Sincan Prison in Ankara.

  • In Brief

    • Case Comprehensive Cancer Center earns “exceptional” rating, $31.9M in NCI grants
    • UPMC to advise cancer treatment center in Beijing
    • UPMC and Pitt open genome center for precision medicine, immunotherapy
    • MSKCC expands its presence in Northern New Jersey
  • TCCL Logo

  • Clinical Roundup

    • Lynparza delays disease progression in phase III trial in first-line ovarian cancer
    • Tecentriq + chemo increase OS, PFS in untreated extensive stage small cell lung cancer
    • Trifluridine and tipiracil meet OS endpoint in phase III trial
    • ONS develops hazardous drugs safe handling toolkit for oncology nurses
  • Drugs & Targets

    • FDA approves Braftovi + Mektovi combination in a melanoma indication
    • Kymab, Roche agree to evaluate KY1044, anti-PD-L1 immunotherapy in solid tumors
    • FDA grants orphan drug designation for CPI-613 for Burkitt lymphoma
  • CTEP Protocol

    NCI Trials for June

    The National Cancer Institute Cancer Therapy Evaluation Program approved the following clinical research studies last month.

    For further information, contact the principal investigator listed.