Issue 5 - Feb 1, 2019
  • 20-year follow-up data are in: Prostate cancer prevention works; concerns about high-grade disease dismissed

    Prostate cancer is the most common solid tumor in men. It has been estimated that 60-75 percent of men will have histologic evidence of prostate cancer during their lifetime and that 2-4 percent of men will die of the disease. African American men are at a greater risk of diagnosis and death.

  • Guest Editorial

    The Prostate Cancer Prevention Trial and nine lessons in prostate cancer medicine

    The publication by Ian M. Thompson and colleagues in last week’s New England Journal of Medicine regarding long term follow-up of patients in the NCI-sponsored Prostate Cancer Prevention Trial (PCPT) marks a good opportunity to review and reflect on the history of the trial and the past 30 years of prostate cancer medicine.

  • Real-World Evidence

    Gottlieb: FDA to expand real-world data infrastructure to enhance AI capabilities

    FDA is enhancing its ability to handle real-world evidence by training reviewers in data science via a curriculum on machine learning and artificial intelligence, said FDA Commissioner Scott Gottlieb.

  • Industry a no-show as Sens. Grassley and Wyden hold hearing on drug pricing

    Earlier this week, the Senate Committee on Finance convened what is likely to be the first in a series of hearings focused on the rising costs of prescription drugs, oncology drugs among them.

  • In Brief

    • Califano named physician-in-chief of Moores Cancer Center
    • NYU receives anonymous $75M gift to establish center for blood cancers
    • Ross Mitchell named artificial intelligence officer at Moffitt
    • Sagar Lonial awarded Gray Family Chair in Cancer at Winship
    • Silvia Formenti and Heather McArthur awarded SU2C Laura Ziskin Prize
    • Helen Heslop named by SU2C to lead ‘Dream Team’
    • Robert Prins receives grant to research brain tumor treatments
    • Johns Hopkins Greenberg Bladder Cancer Institute Awards focused on bladder cancer in women
    • ASCO names advance of the year: progress in treating rare cancers
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  • Trials & Tribulations

    Glioblastoma patient is first to receive treatment under Right to Try. Our question is Why?

    University of California, Irvine patient with glioblastoma recently received an experimental cancer vaccine from the U.S. subsidiary of Brussels-based Epitopoietic Research Corp. (ERC-USA). While most cases of patients receiving experimental medical treatment are not particularly newsworthy, this one was.

  • Clinical Roundup

    • Study incorporates patient feedback into better cancer treatments
    • Patients getting placebo allowed to cross to Erleada as TITAN results unblinded
    • Antioxidants may enhance chemotherapy treatment for brain tumor
  • Drugs & Targets

    • Lung-MAP precision medicine trial expands
    • Alimta + Keytruda and platinum chemo for NSCLC gets FDA label expansion
    • Trovagene and PoC Capital agree to fund clinical development of onvansertib in metastatic colorectal cancer
Issue 4 - Jan 25, 2019
Issue 3 - Jan 18, 2019
  • Thomas Jefferson University vying to acquire venerable but troubled Fox Chase Cancer Center

    Thomas Jefferson University is vying to acquire Fox Chase Cancer Center from its current owner, Temple University, the two institutions announced Jan. 10.

  • New MSK rules prohibit service on boards of for-profit entities in healthcare

    An internal task force formed to investigate conflicts of interest at Memorial Sloan Kettering Cancer Center has produced three initial recommendations that codify the moratoria that were put in place after multiple ethics transgressions at the cancer center were revealed by The New York Times and ProPublica last fall.

  • Guest Editorial

    Waun Ki Hong– A Career of Vision

    On Jan. 2, my friend and long-time mentor Waun Ki Hong passed away. In thinking about what Ki did for me personally and the impact he had on the lives and professional careers of so many people, I pulled out a speech I gave at his retirement celebration at MD Anderson on Aug. 15, 2014. I was struck that even in his passing so many of my thoughts ring true today. Perhaps this will give readers of The Cancer Letter a sense of the man.

  • In Brief

    • Wasif Saif, Louis Potters, Matthew Weiss named deputy physicians in chief at Northwell Health Cancer
    • Duke partners with Teen Cancer America, First Citizens Bank to enhance teen and young adult oncology program
    • Adi Gazdar researcher at UT Southwestern, NCI dies at 81
  • Funding Opportunities

    LUNGevity Foundation issues an RFA for 2019 Career Development Awards for Translational Research in Lung Cancer

    LUNGevity has issued a Request for Applications for translational research for Career Development Awards that will be granted in 2019. The RFA is available on the LUNGevity website and is also posted on the proposalCENTRAL website.

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  • Trials and Tribulations

    Giving every patient an opportunity to participate in and benefit from cancer progress

    Last week, the American Cancer Society released its annual Facts and Figures report, showing that we continue to make exceptional progress against cancer, most notably with a 27 percent decline in the death rate across all cancer types over the last 25 years.

  • Clinical Roundup

    • Keytruda reduced risk of death vs. chemo in esophageal carcinoma
    • Array Biopharma announces 15.3 months median overall OS from phase III BEACON CRC trial in colorectal cancer
  • Drugs & Targets

    • FDA approves Cabometyx for previously treated hepatocellular carcinoma
    • European Commission approves Opdivo + low-dose Yervoy in RCC
    • QIAGEN receives approval for EGFR test in lung cancer as companion diagnostic in Japan
    • FDA accepts sBLA for Tecentriq + Abraxane and carboplatin for lung cancer