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Issue 46 - Dec. 15, 2017
  • “We’re gonna free the data,” Sharpless pledges at NCI Town Hall

    In his first talk to  NCI staff, director Norman “Ned” Sharpless presented himself as an institute insider—highlighting his career-long relationships with NCI and its “legends,” demonstrating his grasp of the institute’s agenda and research portfolio.

  • Five health systems join Strata Oncology network to sequence and match patients to targeted therapy trials

    Five health care systems have joined a precision oncology network that sequences patients’ tumors at no cost and matches patients to clinical trials.

  • As FDA, AHRQ spar over incidence estimates for uterine sarcomas, FDA reiterates recommendation to restrict power morcellation

    About one in 225 to one in 580 women who undergo surgery for fibroids may have hidden uterine cancers, FDA concluded in a recent review of medical studies published over the past four years.

    The updated estimate is generally consistent with one contained in the agency’s 2014 review, FDA officials said in a statement Dec. 14. Three years ago,  the agency estimated that  one in 350 women undergoing such surgery may have a previously undiagnosed sarcoma.

  • Anticipating fundamental change in oncology

    In 2017, The Cancer Letter’s readership grew by over 40 percent and the number of page views has nearly doubled from the 2016 level.

    On an average day in 2017, our website got over 1,700 visits and over 12,500 page views. By way of comparison, in 2016, we gauged 1,200 visits and 6,800 page views. We are losing the right to call ourselves a small publication.

  • In Brief

    • AACR urges House-Senate conference to remove tax bill provisions penalizing future scientists, patients, survivors
    • 2017 AACR-Bayer Innovation and Discovery Grants recipients announced
    • USPSTF recommends against hormone therapy for preventing chronic conditions 
    • Jason Incorvati joins hem/onc department at New Fox Chase East Norriton Campus
  • Drugs and Targets

    • Fate Therapeutics completes technology transfer and starts IND-enabling manufacture of FT500
Issue 45 - Dec. 8, 2017
  • Building a “hybrid” center by the Beltway, Trump pursues vision of a new national research network

    As he goes about the task of building a cancer center, Donald “Skip” Trump has to align the money, the real estate, the recruitment—all the customary components of an institution.

    Sure, all of this is more complex because Trump is building the Inova Schar Cancer Institute in hyper-competitive and wealthy Northern Virginia, literally by the outer loop of the Beltway.

  • FDA considers using data from approved indications to support regular approvals of sNDAs based on intermediate endpoints

    FDA officials are floating a proposal for a review process informally dubbed “reverse accelerated approval.”

    This mechanism would come into play in situations where the data that have already been provided to the agency may justify approval of supplemental indications.

  • Guest Editorial

    Tobacco companies finally have to say smoking causes cancer

    These statements may not be breaking news for oncologists and other physicians, who should have been aware of the lethal nature of cigarette smoking at least since the publication of the first Surgeon General’s report on Smoking and Health more than half a century ago.

  • In Brief

    • William Oh named deputy director of Tisch Cancer Institute
    • Pisters embarks on “listening tour” at MD Anderson
    • Viviane Tabar named chair of the department of neurosurgery at MSK
    • Aradhana Ghosh named vice president of oncology at Syapse
    • NCI awards $16 million grant to PHSU and Moffitt to strengthen tissue bank, reduce health disparities
    • New national clinical trial investigated link between diabetes and pancreatic cancer
    • Mount Sinai’s Sundar Jagannath wins MMRF award
    • AACR urges Congress to reach bipartisan budget agreement
  • Drugs and Targets

    • FDA grants Avastin full approval for glioblastoma
November 2017PDF

 

Hematologic malignancies

CD22 CAR-T therapy shows results in leukemia study

A new type of CAR-T therapy that targets the protein CD22 helped achieve remission in nearly 60 percent of leukemia patients who had failed or relapsed on other treatments, according to a paper published in Nature Medicine.

 

Immunotherapy

Mount Sinai researchers develop first mathematical model for predicting patient response to immunotherapy

Researchers at the Icahn School of Medicine at Mount Sinai have created the first mathematical model that can predict how a cancer patient will benefit from certain immunotherapies, according to a study published in Nature.

 

Lung cancer

Phase III study shows Tecentriq and Avastin plus chemo reduced risk of disease progression or death in advanced lung cancer

Genentech said the phase III IMpower150 study met its co-primary endpoint of progression-free survival and demonstrated that the combination of Tecentriq (atezolizumab) and Avastin (bevacizumab) plus chemotherapy (paclitaxel and carboplatin) provided a statistically significant and clinically meaningful reduction in the risk of disease worsening or death compared to Avastin plus chemotherapy in the first-line treatment of people with advanced non-squamous non-small cell lung cancer.

 

Breast Cancer

Novartis reports positive results from phase III trial of Kisqali for advanced or metastatic breast cancer

 

Genitourinary cancers

Clinical data for CXCR4 inhibitor, Inlyta showa 29% ORR in clear cell renal cell carcinoma

 

Brain tumors

Ziopharm announces positive updated results of Ad-RTS-hIL-12 study in brain cancer

 

NCI CTEP-Approved Trials for November

 

Regulatory actions

FDA approves adjuvant indication for Sutent in renal cell carcinoma

  
CCL Nov 2017 - Dec. 7, 2017