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March 2017PDF

 

Multiple Myeloma

Carfilzomib produces OS benefit vs. bortezomib in relapsed, refractory disease

Amgen announced positive results from a planned overall survival interim analysis of the Phase III head-to-head ENDEAVOR trial.

 

Chronic Myeloid Leukemia

NEJM publishes long-term results of Gleevec for 1,106 patients worldwide

The New England Journal of Medicine published results from a nearly 11-year follow-up study, that showed an estimated overall survival rate of 83.3 percent.

 

Breast Cancer

Phase III MONARCH 2 study of abemaciclib meets primary endpoint of PFS

Eli Lilly and Co. said its MONARCH 2 trial of abemaciclib met the primary endpoint of progression-free survival. The phase III study evaluated abemaciclib, a cyclin-dependent kinase  4 and CDK 6 inhibitor, in combination with fulvestrant in women with hormone-receptor-positive, human epidermal growth factor receptor 2-negative, advanced breast cancer who have relapsed or progressed after endocrine therapy.

 

Ovarian Cancer

Olaparib phase III SOLO-2 trial demonstrates significant PFS benefit in BRCA-mutated disease

AstraZeneca presented data from the confirmatory Phase III SOLO-2 trial demonstrating a statistically significant and clinically meaningful improvement of progression-free survival among patients treated with Lynparza (olaparib) compared to placebo.

 

Lung Cancer

Proton therapy offers treatment possibility for recurrent lung cancer

 

Bladder and Prostate Cancers

In phase II studies Apatorsen improved outcomes in bladder, prostate cancers

 

Medulloblastoma

St. Jude study reveals how an enzyme puts the brakes on aggressive disease

 

Health Disparities

Black and Hispanic women in Connecticut less likely to undergo gene expression profiling

 

NCI CTEP-Approved Trials for March

 

Regulatory Actions

Bavencio receives accelerated approval for Merkel cell carcinoma

CCL March 2017 - Mar. 30, 2017
Issue 12 - Mar. 24, 2017
Issue 11 - Mar. 17, 2017