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April 2017PDF

 

Breast cancer

Phase III abemaciclib study shows PFS improvement at interim analysis

Eli Lilly and Co. said that following a pre-planned interim analysis for MONARCH 3, the trial met its primary endpoint of demonstrating statistically significant improvement in progression-free survival. In addition, improvement was shown in a key secondary endpoint of objective response rate.

 

Hematologic malignancies

Blinatumomab produced remission in high-risk patients with Ph+ B-Cell precursor acute lymphoblastic leukemia

Amgen announced that the Journal of Clinical Oncology published results from the Phase 2, open-label ALCANTARA study evaluating the efficacy and safety of Blincyto (blinatumomab) in patients with Philadelphia chromosome-positive relapsed or refractory B-cell precursor acute lymphoblastic leukemia who had failed at least one second-generation or later tyrosine kinase inhibitor.

 

Pancreatic cancer

SWOG DMC says PEGPH20 unlikely to demonstrate OS improvement

Halozyme Therapeutics Inc. announced it has been informed by SWOG, an independent network of researchers that design and conduct cancer clinical trials, that the SWOG phase Ib/II trial evaluating PEGPH20 plus modified FOLFIRINOX chemotherapy versus modified FOLFIRINOX alone in patients with previously untreated metastatic pancreas cancer has been temporarily closed to enrollment.

 

Childhood cancer

St. Jude study finds childhood cancer survivors would likely benefit from genetic screening

 

Prostate cancer

Active surveillance preserves quality of life for prostate cancer patients, Vanderbilt study concludes

 

Skin cancer

Gene-based blood tests identify more skin cancers

 

Guidelines

ASTRO guideline establishes standard of care for curative treatment of oropharyngeal cancer with RT

 

NCI CTEP-Approved Trials for April

 

Regulatory actions

Tecentriq receives accelerated approval as initial treatment for advanced bladder cancer

CCL April 2017 - May. 1, 2017
Issue 17 - Apr. 28, 2017
  • Beckerle reinstated as director of Huntsman Cancer Institute

    A week after her abrupt firing, Mary Beckerle is back in her job as director and CEO of the Huntsman Cancer Institute.

    The remarkable turnaround comes eight days after the same leadership fired Beckerle—a highly regarded scientist who has led the cancer center since 2006—with no justification other than that she serves at the pleasure of the senior vice president for health sciences (The Cancer Letter, April 21).

  • U of Utah department chairs urge colleagues to sign petition supporting Vivian Lee

    The text of the petition follows:

    This is a critical moment. It is bigger than any one of us and it will have implications for our university and health system for years—maybe decades—to come.

    If we let the commentary and mis-characterizations of the past week go unchecked, our institution, reputation, and leadership will be damaged beyond repair.

  • Soon-Shiong and The Art of the Deal:

    Billionaire gives $12M to the U of Utah, takes $10M in orders for his company

    Under ordinary circumstances, a $12 million gift from a charitable foundation to a university is a cause for celebration.

    Indeed, in September 2014, the university put on considerable hoopla to mark a gift from three charitable entities connected to the pharmaceuticals billionaire Patrick Soon-Shiong (The Cancer Letter, April 21).

  • Tom Curran: Contract between NantHealth and U of Utah “seems a bit expensive”

    Starting in 2008, I worked closely with Peter Phillips to establish the Children’s Brain Tumor Tissue Consortium designed to generate a biorepository of rare biospecimens, with associated clinical information and genomic data, that could be shared with the research community.

  • Conversation with The Cancer Letter

    No future collaborations with NantHealth are planned, U of Utah says

    The Cancer Letter sent the following questions to the University of Utah and a nearly identical list of questions to Soon-Shiong’s spokesperson. Julie Kiefer, manager, scientific communications at the University of Utah, provided responses to these questions. No response was received from Soon-Shiong’s offices.

  • In Brief

    • SU2C awards $1 million to four research teams through Phillip A. Sharp Awards
    • Aurora Cancer Care launches precision medicine program
    • Cold Spring Harbor to collaborate with Chan Zuckerberg Initiative
    • Jason Chesney named director of University of Louisville
    • Kimberly Stegmaier wins St. Baldrick’s Foundation Arceci Innovation Award
    • Lori Brown named ONS’s first chief experience officer
    • Western IRB, Huron form alliance to serve research programs at academic centers
  • Drugs and Targets

    • FDA approves midostaurin combination for AML; Companion diagnostic also approved
    • FDA expands indications for regorafinib in hepatocellular carcinoma
    • FDA grants accelerate approval for brigatinib for ALK-positive NSCLC
    • FDA takes action against 14 companies for selling illegal cancer treatments
    • DelMar collaborates with Duke to study VAL-083 as front-line GBM treatment
Issue 16 - Apr. 21, 2017