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Issue 11 - Mar. 13, 2020
TCL46-11 (695 downloads)

  • Guest Editorial

    COVID-19 and the cancer patient: A call to action for balancing cancer care and viral risk

    As COVID-19 has now officially been declared a source of the pandemic, with increasing incidence across the nation, it is without question that the needs of patients with particular vulnerabilities should garner particular attention.

  • Pandemic: Bracing for coronavirus surge

    The COVID-19 pandemic will affect every aspect of cancer care and cancer research.

  • Conversation with The Cancer Letter

    Is your cancer center ready for COVID-19?

    The Cancer Letter spoke with leaders from the Fred Hutchinson Cancer Research Center, MD Anderson Cancer Center, University of California, Los Angeles, and Robert H. Lurie Comprehensive Cancer Center of Northwestern University to gauge the impact of coronavirus.

  • Conversation with The Cancer Letter

    What to expect: Oncology’s response to coronavirus in Italy

    “It’s like being in a war”

     To get a sense of how COVID-19 will affect oncology in the U.S., The Cancer Letter called Giuseppe Curigliano, associate professor of Medical Oncology at University of Milano and the head of the Division of Early Drug Development at European Institute of Oncology, Italy, who is based in the Lombardy region—the epicenter of the outbreak.

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  • Trials & Tribulations

    A conversation about COVID-19: reflecting on first cases in Kansas

    The following is a transcript from a weekly Facebook Live program, where Roy Jensen, director of The University of Kansas Cancer Center and Kansas Masonic Cancer Research Institute, interviews cancer researchers, clinicians, and patients.

  • Clinical Roundup

    • FDA encourages inclusion of older adult patients in cancer clinical trials
    • Phase III GY004 for Cediranib and Lynparza doesn’t meet PFS endpoint in ovarian cancer indication
    • Copper IUDs less likely to contribute to cervical cancer than hormonal IUDs

  • Drugs & Targets

    • FDA grants accelerated approval to nivolumab and ipilimumab combination for hepatocellular carcinoma
    • FDA accepts BLA for biosimilar MYL-1402O in cancer indications
    • FDA grants Breakthrough Therapy Designation for JNJ-6372 in NSCLC indication
    • Thermo Fisher Scientific collaborates with Janssen to co-develop companion diagnostic for cancer
    • European Commission approves Venclyxto in CLL indication
Issue 10 - Mar. 6, 2020
TCL49-10 (220 downloads)

  • Coronavirus vs. oncology: Meeting cancellations, travel restrictions, fears about drug supply chain

     Forecasts of the inevitable spread of coronavirus can be difficult to ignore, especially at a time when many of us are making travel plans for this spring’s big cancer meetings.

  • Moffitt execs were made aware of Howard McLeod’s China activities, ousted researcher’s attorney says

    Howard McLeod, one of the six researchers ousted at Moffitt Cancer Center under allegations of undisclosed conflicts of interest stemming from their work in China, is publicly disputing his former employer’s characterization of his involvement with academic institutions there.

  • An Appreciation

    Clara Bloomfield, blood cancer expert and destroyer of glass ceilings, dies at 77

    By Electra D. Paskett, Ph.D.

    In 1989, I joined Cancer and Leukemia Group B and was introduced into the clinical trials world and a mighty force for good, Dr. Clara D. Bloomfield.

  • In Brief

    • Roswell Park signs on to participate in ASCO’s CancerLinQ
    • IASLC names research award after Fred R. Hirsch
    • Dunmire, Godfrey, Nissenbaum named to LLS leadership team
    • Research!America: Republicans, Democrats should prioritize research investment
    • John Sampson named president of the Duke Health physician practice
    • 49 cancer care facilities receive outstanding achievement award from American College of Surgeons Commission on Cancer
    • Fox Chase Cancer Center announces name, recertification for Palliative Care Program

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  • Clinical Roundup

    • Cancer survival rates improve for young adults
    • Colorectal cancer burden shifts to younger adults
    • Phase III BOSTON study meets primary endpoint with significant increase in PFS
    • Keytruda meets PFS primary endpoint in phase III KEYNOTE-204
    • From scorpion to immunotherapy: City of Hope scientists repurpose toxin for first-of-its kind CAR-T cell therapy for brain tumors
    • VBI Vaccines phase I/II study demonstrates OS benefit for VBI-1901 vaccine responders in recurrent GBM

  • Drugs & Targets

    • FDA approves Sarclisa in patients with previously treated MM
    • FDA grants RMAT designation for CD30 CAR-T cell therapy in Hodgkin lymphoma indication
    • FDA grants tipifarnib Fast Track designation in T-cell lymphomas
    • Thermo Fisher Scientific to acquire QiagenN.V.

  • NCI Trials

    NCI Trials for March 2020

    The National Cancer Institute Cancer Therapy Evaluation Program approved the following clinical research studies last month. 

Issue 9 - Feb. 28, 2020
TCL46-09 (211 downloads)

  • ODAC: Thumbs up for Eli Lilly’s Cyramza, thumbs down for STEBA’s Tookad

    The FDA Oncologic Drugs Advisory Committee Feb. 26 voted down a vascular-targeted photodynamic therapy for early-stage, low-risk prostate cancer and, in a narrow vote, recommended approval for a combination of a VEGF receptor 2 antagonist and an EGFR-targeting tyrosine kinase inhibitor for front-line treatment of EGFR-positive non-small cell lung cancer.

  • FDA approved 11 new agents, 30 supplemental indications in cancer in 2019

    Last year, FDA approved 11 new drugs and biologics as well as 30 supplemental indications and four biosimilars, according to commentary by FDA officials published in Nature Reviews.

  • In Brief

    • Jennifer Cullen named associate director of Cancer Population Sciences at Case CCC
    • Aaron Gerds named medical director of Clinical Research Office at Case CCC
    • Cantley, Bernstein, Pui receive Medal of Honor award from ACS

     

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  • Clinical Roundup

    • Immunotherapy combination effective for patients with high-grade neuroendocrine cancer
    • Definitions of malnutrition apply differently depending on cancer type

  • Drugs & Targets

    • FDA approves neratinib for metastatic HER2-positive breast cancer
    • FDA accepts sNDA for Zejula in ovarian cancer indication
    • FDA grants RMAT designation to CD30 CAR-T Cell Therapy in hodgkin lymphoma indication
    • PMC report: FDA addressed rare diseases, expanded cancer treatment and targeted therapies in 2019
    • Boehringer Ingelheim and Trutino Biosciences collaborate to grow cancer immunology portfolio with novel cytokine platform
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