publication date: May. 3, 2019

Trials & Tribulations A comparison of study designs for estimating overdiagnosis in cancer screening Barnett S. Kramer

Barnett S. Kramer

Contractor, NCI Division of Cancer Control and Population Sciences, Office of the DCCPS Director

Former director of the NCI Division of Cancer Prevention

 

Phililp Prorok_edit

Philip C. Prorok

Contractor, NCI Division of Cancer Prevention, Office of the Director, Division of Cancer Prevention

Former chief of the Biometry Research Group at DCP

 

Overdiagnosis is defined as the diagnosis of an asymptomatic cancer that would not have become clinically evident during the person’s lifetime in the absence of screening or similar activities, such as diagnostic imaging tests that reveal “incidentalomas.”

The whole concept of overdiagnosis seems counterintuitive to the public and even to many clinicians, because the traditional view, encouraged by public health messages and by medical training, is that cancer is lethal unless detected early. This core belief system has driven the quest for increasingly sensitive screening tests that can detect as many asymptomatic cancers as possible.

Continue reading A comparison of study designs for estimating overdiagnosis in cancer screening

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Copyright (c) 2018 The Cancer Letter Inc.