publication date: Nov. 30, 2018

Clinical Roundup Brain cancer immunotherapy SurVaxM extends survival

The latest results from an ongoing clinical study incorporating the immunotherapy SurVaxM as part of combination treatment for glioblastoma show that the investigational drug is safe, well-tolerated and extended survival even among the hardest-to-treat subgroups of patients.

These new findings—including a molecular analysis detailing study participants’ levels of a key biomarker, MGMT—were presented earlier this month at the Society for Neuro-Oncology Annual Meeting in New Orleans.

Robert Fenstermaker and Michael Ciesielski are the co-inventors of SurVaxM, an investigational immunotherapy has shown promise as part of a treatment combination for glioblastoma brain tumors.

With standard glioblastoma therapy—surgery followed by chemotherapy (temozolomide, also known as Temodar), radiation therapy and adjuvant temozolomide—the median overall survival is 15 months.

SurVaxM is a synthetic compound that stimulates the immune system to target a cancer molecule called survivin, a molecule that is highly expressed in glioblastoma and many other cancers.

Sixty-three patients with newly diagnosed glioblastoma were treated with standard of care plus SurVaxM as part of this phase II trial.

The study revealed that:

This treatment combination was well-tolerated. Observed side effects were generally mild, with no regimen-limiting toxicity attributable to SurVaxM

96.7 percent of patients did not experience disease progression within the first six months … Continue reading Brain cancer immunotherapy SurVaxM extends survival

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