publication date: Jul. 6, 2018

Clinical Roundup

Tecentriq + Abraxane reduced risk of disease worsening, death in triple negative breast cancer

Genentech, a member of the Roche Group, announced that phase III IMpassion130 study met its co-primary endpoint of progression free survival.

Results demonstrated that the combination of Tecentriq (atezolizumab) plus chemotherapy (Abraxane), as an initial treatment, significantly reduced the risk of disease worsening or death in people with metastatic or unresectable locally advanced triple negative breast cancer. Overall survival is encouraging in the PD-L1 positive population at this interim analysis, and follow up will continue until the next planned analysis.

Safety in the Tecentriq plus nab-paclitaxel arm appeared consistent with the known safety profiles of the individual medicines, and no new safety signals were identified with the combination. Results will be presented at an upcoming medical meeting and will be submitted to global health authorities, including FDA and European Medicines Agency.

This is the third positive phase III study that includes Tecentriq and nab-paclitaxel as part of a treatment regimen. Currently, Genentech has seven ongoing phase III studies investigating Tecentriq in TNBC.

IMpassion130 study is a phase III multicenter, randomized, double-blind study evaluating the efficacy, safety, and pharmacokinetics of Tecentriq and nab-paclitaxel compared with placebo in combination with nab-paclitaxel in people with locally advanced or metastatic TNBC who have not received prior systemic therapy for metastatic breast cancer.

The study enrolled 902 people who were randomized equally (1:1). The co-primary endpoints were progression-free survival per investigator assessment (RECIST 1.1) and overall survival. 

PFS and OS were assessed in all randomized participants [intention-to-treat] and in those whose disease expressed the PD-L1 protein. Secondary endpoints included objective response rate, duration … Continue reading Tecentriq + Abraxane reduced risk of disease worsening, death in triple negative breast cancer

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