publication date: Oct. 20, 2017
Conversation with the Cancer Letter Rosenberg: Yescarta is going to be lifesaving for patients with lymphomas
Chief of the Surgery Branch, senior investigator, and head of the Tumor Immunology Section at NCI’s Center for Cancer Research
When Eric Karlson’s lymphoma went into complete regression in 2009, Steven Rosenberg and James Kochenderfer knew they were making history—for the first time, they had cured a patient by using genetically modified cell therapy, specifically, anti-CD19 CAR-T cells.
Karlson, a marine-construction worker on Marco Island, FL, has been disease-free for almost nine years. Rosenberg is chief of the Surgery Branch, senior investigator, and head of the Tumor Immunology Section at NCI’s Center for Cancer Research, and Kochenderfer is an investigator in the Experimental Transplantation and Immunology Branch.
On Oct. 18, FDA approved Yescarta (axicabtagene ciloleucel) to treat adult patients with certain types of large B cell lymphoma who have not responded to or who have relapsed after at least two other kinds of treatment. The complete remission rate after treatment with Yescarta was 51 percent.
The therapy is the result of Kochenderfer and Rosenberg’s work on cell-based gene therapy in the intramural … Continue reading Rosenberg: Yescarta is going to be lifesaving for patients with lymphomas
To access this members-only content, please log in.
If you're not a subscriber why not join today?
If you believe you should be able to view this area but cannot log in, then please contact us
and we will try to rectify this issue as soon as possible.
To gain access to the members only content click here
You will be given immediate access to premium content on the site.Click here to join.