Researchers with The Cancer Genome Atlas Network found that stomach cancers fall into four distinct molecular subtypes.
Previous attempts to examine the clinical characteristics of gastric cancer were hindered by how differently cancer cells can look under a microscope, even when from the same tumor. Researchers say the new classification system can serve as a valuable adjunct to the current pathology classification system, which has two categories: diffuse and intestinal.
The researchers identified the new subgroups through complex statistical analyses of molecular data from 295 tumors. They used six molecular analysis platforms including DNA sequencing, RNA sequencing, and protein arrays. The study was published in Nature.