publication date: Oct. 20, 2016

Renal Cell Carcinoma Durable Responses Seen With Opdivo and Yervoy in Updated Analysis

Updated results of the phase I CheckMate-016 trial include findings for the Opdivo (sunitinib) and Yervoy (pazopanib) combinations showed the overall response rate (ORR; secondary endpoint) was 40.4% (n=47) in both arms.

The two drugs are sponsored by Bristol-Myers Squibb.

The trial, which now has two years of follow-up, compared 3 mg/kg plus Yervoy 1 mg/kg in one arm with Opdivo 1 mg/kg plus Yervoy 3 mg/kg in the other arm.

Of the 38 responders in both treatment arms, 39.5% (n=15) had an ongoing response, with a median duration of response of 20.4 months (95% CI: 8.54 – NE) in the Opdivo 3 mg/kg plus Yervoy 1 mg/kg arm and 19.7 months (95% CI: 8.08 – NE) in the Opdivo 1 mg/kg plus Yervoy 3 mg/kg arm.

The overall survival rate at 12 months was 81% and 85% for Opdivo 3 mg/kg plus Yervoy 1 mg/kg arm and Opdivo 1 mg/kg plus Yervoy 3 mg/kg arm, respectively, and at 24 months was 67% and 70%, respectively. There were fewer Grade 3/4 treatment-related adverse events reported in the Opdivo 3 mg/kg plus Yervoy 1 mg/kg arm (38.3%) than with Opdivo 1 mg/kg plus Yervoy 3 mg/kg arm (61.7%).

These results were presented at the 2016 European Society for Medical … Continue reading CCL Oct 2016 – Durable Responses Seen With Opdivo and Yervoy in Updated Analysis

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