publication date: Oct. 20, 2016

Retinoblastoma Triple-drug Chemo with Topotecan Helps Preserve Vision in Patients

Revamping front-line multi-drug chemotherapy for retinoblastoma to include topotecan helped to maintain high cure rates for the eye cancer while preserving patients’ vision and reducing their risk of treatment-related leukemia. Results of the St. Jude Children’s Research Hospital study appear online today in the Journal of Clinical Oncology.

“This 10-year follow-up study shows for the first time that topotecan can be used in front-line therapy to help reduce exposure of retinoblastoma patients to etoposide, which is associated with secondary leukemia,” said first and corresponding author Rachel Brennan, M.D., an assistant member of the St. Jude Department of Oncology. “We expected patients to be cured, but we also found more than 80 percent of patients had measurable vision.”

Retinoblastoma is a malignant tumor that begins in the retina, the light-sensing tissue at the back of the eye. It is diagnosed in 250 to 300 children annually in the U.S.; most are less than 2 years old when the tumor is discovered.

For retinoblastoma patients in the U.S. whose disease is confined to the eye, the cure rate exceeds 95 percent. But the widely used triple-drug chemotherapy designed to help preserve the eyes and vision of retinoblastoma patients includes etoposide, a drug that leaves survivors at risk for acute myeloid leukemia.

Continue reading CCL Oct 2016 – Triple-drug Chemo with Topotecan Helps Preserve Vision in Patients

To access this members-only content, please log in.
If you're not a subscriber why not join today?
If you believe you should be able to view this area but cannot log in, then please contact us and we will try to rectify this issue as soon as possible.
To gain access to the members only content click here to subscribe.
You will be given immediate access to premium content on the site.
Click here to join.

Copyright (c) 2017 The Cancer Letter Inc.